MSN, Infection Prevention and Control The requirements for a Masters of Science in Nursing (MSN) Infection Prevention and Control requires the nurse to have a Registered Nurse Degree (RN). We have all been influenced by the recent Pandemic of the H1N1 influenza. More and more healthcare systems will need to hire nurses trained in infection control and prevention. Nurses with a specialization in infection prevention and control can provide entry into this important emerging field.